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ASCP MEDICAL LABORATORY TECHNICIAN - MLT(ASCP) Sample Questions:

1. Which one of the following conditions is NOT associated with hereditary spherocytosis?

A) Increased osmotic fragility
B) An MCHC greater than 37%
C) Extravascular hemolysis
D) Intravascular hemolysis

2. One method of calculating a glomerular filtration rate is using creatinine and urine volume to determine creatinine clearance. The equation is as follows:
Creatinine Clearance = (urine creatinine X urine flow rate) / plasma creatinine; where urine flow rate = volume in mL /24 hours x h/60 min) In this case = creatinine clearance = 124 X (2200/24 x hour/60) / 2 = 94.7 or 95 ml/min What is the glomerular filtration rate for a patient with a serum creatinine of 2 mg/dL, if the urine creatinine was 124 mg/dL and the urine volume was 2.2 L/24 hrs?

A) 95 mL/min
B) 1.36 mL/min
C) 9.5 mL/min
D) 13.6 mL/min
E) 136 mL/min

3. A beam splitter is employed in a dual beam spectrophotometer.
Which of the following is not a component of a basic single beam spectrophotometer:

A) Cuvette
B) Prism
C) Light source
D) Beam splitter

4. Coumarin derivatives inhibit the vitamin K dependent Factors (II, VII, X) which can be measured with the PT and monitored frequently with the INR assay.
Hematology
Warfarin-based (coumarin derivative) oral anti-coagulant therapy is commonly monitored with :

A) APTT
B) PT/INR
C) Thrombin time
D) APTT and PT

5. Alpha thalassemia is a hemolytic anemia. In most hemolytic anemias the LD and bilirubin are increased while the haptoglobin is decreased. However, because haptoglobin binds to the alpha chain portion of hemoglobin, it usually remains at normal levels due to the absence of alpha chains in the destroyed cells.
Which set of chemistry results would most likely occur during hemolytic crisis in alpha thalassemia intermedia?

A) Normal LD and bilirubin, and decreased haptoglobin
B) Decreased lactate dehydrogenase (LD)and bilirubin, and increased haptoglobin
C) Increased LD and bilirubin,and decreased haptoglobin
D) Increased LD and bilirubin, and normal haptoglobin

Solutions: