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American Society of Microbiology ABMM Sample Questions:

1. A patient with recent abdominal surgery develops a fever, abdominal pain, and a wound infection. Gram stain of the wound exudate reveals a mixture of Gram-negative rods and Gram-positivebacilli. Anaerobic culture yields a foul-smelling, Gram-negative rod that is bile-esculin positive. The MOST likely organism is:

A) Bacteroides fragilis
B) Clostridium perfringens
C) Peptostreptococcus anaerobius
D) Escherichia coli

2. A research laboratory is investigating the mechanisms of antigenic variation in Trypanosoma brucei, the causative agent of African trypanosomiasis. The parasite evades the host immune response by periodically changing its surface coat protein. This process primarily involves:

A) High-frequency point mutations in the gene encoding the variant surface glycoprotein (VSG).
B) RNA interference-mediated silencing of expressed VSG genes followed by activation of a new VSG gene.
C) Segmental gene conversion events involving a large repertoire of silent VSG genes.
D) Recombination between different VSG gene loci on minichromosomes.

3. A patient with a history of travel to an area endemic for schistosomiasis presents with hematuria. Microscopic examination of a urine sediment reveals a large oval egg with a prominent terminal spine. The MOST likely causative agent is:

A) Schistosoma mekongi
B) Schistosoma haematobium
C) Schistosoma japonicum
D) Schistosoma mansoni

4. A patient presents with symptoms suggestive of primary syphilis. Which diagnostic test typically becomes positive earliest in the course of infection?

A) Venereal Disease Research Laboratory (VDRL) test on CSF
B) Rapid Plasma Reagin (RPR)
C) Darkfield microscopy of lesion exudate
D) Treponema pallidum particle agglutination (TP-PA)

5. A research laboratory is developing a novel diagnostic assay for early detection of sepsis. They are investigating the use of host biomarkers that are rapidly upregulated in response to bacterial infection. Which of the following biomarkers has shown promise for differentiating between systemic inflammatory response syndrome (SIRS) and sepsis?

A) Procalcitonin (PCT)
B) Erythrocyte sedimentation rate (ESR)
C) C-reactive protein (CRP)
D) Interleukin-6 (IL-6)

Solutions: